The company announced on Friday that it would propose her election at its annual-general meeting on April 25.
Anglo American chairperson Mark Moody-Stuart said that Ramphele's experience in international financial institutions, together with her knowledge of South African issues, would be of great value to the company.
Ramphele, 58, is currently the chairperson of Circle Capital Ventures, a black economic-empowerment company.
“Anglo American is a world-class company with a commitment to couple business objectives with a wider sense of corporate responsibility. I look forward to contributing to its continued success as a nonexecutive director,” Ramphele said.
Meanwhile, Anglo American South Africa announced that Douglas Ramaphosa, current public affairs head, would be leaving at the end of May to pursue his personal business interests.
He would be replaced by Daniel Ngwepe.
Ngwepe was in the South African foreign service until early 2005.